These cuties are pretty durable under normal travel, play, or what have you. I would not recommend them for pet toys at all.

If you need to wash them, try spot cleaning first. If the mess is more serious than that, you can wash them with a load of soft fabrics on a delicate cycle with cold water, and let them air dry. Do not use bleach (unless you want to change the way the yarn looks forever), & don't put it in the dryer (as the poly-fil fibers inside may get a bit warped & lumpy) unless you have a tumble/ no-heat setting.